physician-scientist, author, editor drerictopol.com

La Jolla, CA
Joined November 2009
This will go down in history as one of science and medical research's greatest achievements. Perhaps the most impressive. I put together a preliminary timeline of some key milestones to show how several years of work were compressed into months.
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The good US news today is that Covid hospitalizations have come down to ~150,000 from their recent peak of 159,000 (21 Jan)
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Below 150,000. And headed down (finally)👍
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Straight talk on a Covid endemic state, new @nature nature.com/articles/d41586-0… by @ArisKatzourakis "There is a widespread, rosy misconception that viruses evolve over time to become more benign."
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"The vaccination programme needs to reach children as well as unvaccinated and partially vaccinated adults to reduce SARS-CoV-2 transmission and associated disruptions to work and education." thelancet.com/journals/lanre… @LancetRespirMed
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Good move by @US_FDA keeping up with the data. We need a lot more Sotrovimab, the only monoclonal antibody that has efficacy vs Omicron @FT by @kiranstacey
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The Omicron wave in the US 4 most populous states (~1/3rd of the population) All but one (TX) are showing solid signs of descent
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ICU and hospitalization data are tracking with this @CovidActNow
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How to reduce your chance of dying from Covid by 99%? Get vaccinated and a booster. One of the most impressive graphs I've seen for the impact of vaccination in the US pandemic (thanks @redouad @OurWorldinData for re-plotting my makeshift graph from earlier today)
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Highlighting the data above are for all ages Graphs for vaccination vs deaths by age groups (w/o booster partitioned):
The US CDC updated its data on deaths by vaccination status. One key takeaway: the large relative reduction in death rates after full vaccination doesn't only apply to older people. Here are weekly deaths among 12-17 years old, 18-29, 30-49, 50-64. [From ourworldindata.org/covid-dea…]
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Now deaths by age groups: 65+, 50-49, 18-49 For each group, death is reduced by 99% for vaccination plus booster compared with unvaccinated (down to zero for youngest age group) ourworldindata.org/grapher/u…
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The absolute risk is provided on each graph per 100,000 people That translates to about 10/100,000 for lives saved across all 18+ age groups or 44/100,000 for lives saved for age 65+ (vaccination + booster)
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Eric Topol retweeted
3 new studies should erase any doubt that boosters are needed for optimal protection against #covid19. When science changes, policy should adapt too. The same national effort for initial vaccinations should now occur for boosters. 🧵@PostOpinions washingtonpost.com/opinions/…
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Adding this important study, the largest household (~12,000) contact study for Omicron and Delta infections and *impact of booster* (3rd) dose vaccination: Infections were reduced OR 0.54, CI 0.40-0.71) Transmission risk reduced OR: 0.72, CI: 0.56-0.92) medrxiv.org/content/10.1101/…
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Data from Switzerland and Chile on the gradient of reduction of death from unvaccinated, to 2-dose vaccinated, to booster @OurWorldinData ourworldindata.org/covid-dea… by @redouad @MaxCRoser thanks @JusDayDa
Similarity in death rate reduction by vaccination and booster in Switzerland and the United States @OurWorldInData and covid.cdc.gov/covid-data-tra… ~99% reduction from unvaccinated to boosted
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In people age 60+, a "3-fold protective effect vs serious illness" from a 4th vaccine dose in Israel (400,000 people with 4th dose vs 600,00 with 3rd dose past 4 months, few details available) timesofisrael.com/health-min…
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Similarity in death rate reduction by vaccination and booster in Switzerland and the United States @OurWorldInData and covid.cdc.gov/covid-data-tra… ~99% reduction from unvaccinated to boosted
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I haven't seen such data reported for other countries to date, which is surprising. If you have, please share. (correction: CDC data from December 2021)
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A potential cause of #LongCovid is persistence of the virus. A new report of an 11-year-old girl with abdominal pain 3 months out and small bowel biopsy positive for #SARSCoV2 virions journals.lww.com/jpgnr/Fullt… by @md_wallach @sunydownstate and colleagues H/T @BrodinPetter
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For J&J vaccine recipients, the immune response generated from an mRNA 2nd shot was superior to a 2nd J&J shot, for neutralizing antibodies, B and T cells cell.com/med/fulltext/S2666-… (P-Pfizer) didn't matter w/ Prior Covid; new @MedCellPress
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Sharp Omicron new case descents in Australia and Ireland 👍 @OurWorldInData
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