We are a group of academic labs around the world that perform biomedical research using the computing power of volunteers | Join us at: foldingathome.org

Washington University in St. Louis, MO
Joined May 2008
Replying to @DNDi @london_lab
The @covid_moonshot project just received key funding from @wellcometrust to put the most promising drug candidates into clinical trials. We hope the first drugs will be available at the end of 2022. All our results will be publicly shared and free for anyone to use. (3/3)
2
16
0
36
Show this thread
🚨BIG NEWS🚨 Our effort to design a patent-free #COVID19 oral antiviral, the @covid_moonshot, has received $10M in funding from the @wellcometrust and @WHO! This funding will pay for preclinical studies of compounds prior to initiating clinical trials! foldingathome.org/2021/09/27… 🧵
6
66
10
237
The @covid_moonshot aims to develop a patent-free, low-cost antiviral. The goal is a shelf-stable pill that prevents severe disease, taken following exposure or becoming symptomatic. Early efforts have yielded remarkable results: nature.com/articles/d41586-0…
1
1
0
21
Oral antivirals will support vaccines and can be manufactured cheaply in large quantities to share with the world! To get there, we first need to complete our optimization process ("Discovery") and enter the “Preclinical” phase. Only after both phases can clinical trials begin!
1
4
0
24
With vaccine supplies still limited globally and the emergence of variants like #Delta, time is of the essence. We hope to reach clinical trials within a year! To do this, the @covid_moonshot has partnered with @DNDi to utilize this new funding from @Wellcometrust!
1
0
0
15
While the majority of funding will finance expensive preclinical studies, part of this funding will help bring on more scientists to help launch @covid_moonshot sprints for primary and backup series optimization! Most recently we just completed Sprint 10: fah-public-data-covid19-moon…
1
2
0
15
This effort is a worldwide collaboration for global health. We are so thankful to you, our folding community, for enabling F@h to help deliver patent-free therapies for global, equitable access! A big shout out to @AWS and @NSF for supporting our contributions to the moonshot!
1
4
0
19
Get your GPUs ready! Our work continues once the first compound enters preclinicial studies: We’re starting to work on 2nd-generation inhibitors against variants! As always, all the results and data from the @covid_moonshot will be made publicly available: postera.ai/moonshot
3
6
1
19
Folding@home retweeted
The tweet that started it all: 🌙🚀 @covid_moonshot has some big news today...
1/ It's been a very busy few weeks in the Walsh group @diamondLightSou but extremely happy to announce that in collaboration with Frank von Delft group’s at Diamond we have been able to perform a full X-ray fragment based drug discovery experiment on the SARS-CoV-2 main protease
Show this thread
3
3
1
52